- Estudiantes FC 2 Zulia FC 1
- Goles: Heiber Díaz 38′ y 72′ (EFC) Yohandrys Orozco 90+2′ (ZFC)
- Carabobo FC 1 Dvo Anzoátegui 0
- Gol: Carlos Ceballos 43′ (CFC)
- Yaracuyanos FC 1 Aragua FC 0
- Gol: John Palacios 64′ (YFC)
- Caroní FC 1 Atlético El Vigía 0
- Gol: Carlos Muñoz 42′ (CFC)
- Atlético Venezuela 2 Zamora FC 1
- Goles: Marcelo Refresquini 57′ y 68′ (AV) Herlyn Cuica 36′ (ZFC)
- Monagas SC 1 CD Lara 1
- Goles: Luis Valencia 9′ (MSC) David Montoya 20′ (CDL)
- Trujillanos FC 0 Dvo Petare 1
- Gol: Evelio Hernández 66’p (DP)
- Caracas FC 1 AC Mineros 0
- Gol: Luis Cabezas 51′ (CFC)
- Dvo Táchira 2 Real Esppor 0
- Goles: Yonathan Del Valle 71′ y Sergio Herrera 87′ (DT)
CLASIFICACION TORNEO APERTURA 2010
| Nº | CLUBES | JJ | JG | JE | JP | GF | GC | PT | DG |
| 1 | Táchira | 16 | 10 | 5 | 1 | 31 | 11 | 20 | 35 |
| 2 | Real Esppor | 16 | 10 | 3 | 3 | 28 | 11 | 17 | 33 |
| 3 | Petare | 16 | 9 | 5 | 2 | 25 | 17 | 8 | 32 |
| 4 | Caracas FC | 16 | 10 | 2 | 4 | 21 | 15 | 6 | 32 |
| 5 | Trujillanos | 16 | 7 | 5 | 4 | 19 | 12 | 7 | 26 |
| 6 | Yaracuyanos | 16 | 6 | 8 | 2 | 20 | 15 | 5 | 26 |
| 7 | Anzoátegui | 16 | 7 | 4 | 5 | 33 | 27 | 6 | 25 |
| 8 | Aragua FC | 16 | 7 | 3 | 6 | 19 | 19 | 0 | 24 |
| 9 | Estudiantes | 16 | 6 | 4 | 6 | 17 | 19 | -2 | 22 |
| 10 | Mineros | 16 | 4 | 7 | 5 | 19 | 19 | 0 | 19 |
| 11 | Zulia FC | 16 | 5 | 3 | 8 | 21 | 27 | -6 | 18 |
| 12 | Monagas | 16 | 4 | 5 | 7 | 24 | 23 | 1 | 17 |
| 13 | Venezuela | 16 | 4 | 4 | 8 | 20 | 30 | -10 | 16 |
| 14 | Carabobo | 16 | 3 | 6 | 7 | 14 | 20 | -6 | 15 |
| 15 | Zamora FC | 16 | 3 | 5 | 8 | 17 | 27 | -10 | 14 |
| 16 | C.D Lara | 16 | 2 | 7 | 7 | 20 | 27 | -7 | 13 |
| 17 | El Vigía | 16 | 1 | 8 | 7 | 16 | 24 | -8 | 11 |
| 18 | Caroní FC | 16 | 3 | 2 | 11 | 10 | 31 | -21 | 11 |
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